Advanced protein glycosylation in diabetes and aging.

نویسنده

  • M Brownlee
چکیده

Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.

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عنوان ژورنال:
  • Annual review of medicine

دوره 46  شماره 

صفحات  -

تاریخ انتشار 1995